Real Madrid without Varane and Bale for Tottenham trip
Varane picked up a thigh problem as Madrid suffered a shock 2-1 defeat in Catalonia on Sunday.
The France international was considered a doubt and trained alone on Monday.
His lack of participation in the match was confirmed a day later with the announcement of Madrid's squad.
Former Spurs star Bale has been out of action since the end of September with a calf problem and, although Zinedine Zidane hinted at the weekend that he could be in line for a return, it appears Wednesday has come too soon for the Wales international to be involved at Wembley.
Our 19-man squad for the match against @SpursOfficial! #RMUCL pic.twitter.com/WQxpC02MWJ— Real Madrid C.F. (@realmadriden) October 31, 2017
Goalkeeper Keylor Navas (thigh) is also sidelined again.
Zidane has been able to include Isco, however, after the Spain midfielder recovered from a knock suffered against Girona.