Higuain in, Mandzukic out of Juve squad for Tottenham trip
Argentina striker Higuain trained on Tuesday and has been declared fit for the second leg of the last-16 tie at Wembley.
The 30-year-old, who scored twice and missed a penalty in last month's 2-2 draw in Turin, missed the Bianconeri's previous two matches with an ankle injury.
His timely return softens the blow of Mandzukic's absence.
The Croatia international is battling a thigh problem and was not among the 21-man party that departed for London on Tuesday.
@ChampionsLeague SQUAD LIST | @OfficialAllegri names a 21-man squad to face @SpursOfficial.#TOTJuve #TOGETHER #UCL pic.twitter.com/Cck6MM6kO6— JuventusFC (@juventusfcen) March 6, 2018