BCDIN3D regulates tRNAHis 3’ fragment processing
by Calder W. Reinsborough, Hélène Ipas, Nathan S. Abell, Ryan M. Nottingham, Jun Yao, Sravan K. Devanathan, Samantha B. Shelton, Alan M. Lambowitz, Blerta Xhemalçe
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by Calder W. Reinsborough, Hélène Ipas, Nathan S. Abell, Ryan M. Nottingham, Jun Yao, Sravan K. Devanathan, Samantha B. Shelton, Alan M. Lambowitz, Blerta Xhemalçe
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by Julie Cocquet, Peter J. I. Ellis, Shantha K. Mahadevaiah, Nabeel A. Affara, Daniel Vaiman, Paul S. Burgoyne
by Yun-Ching Chen, Laura Elnitski
Alternative transcript isoforms are common in tumors and act as potential drivers of cancer. Mechanisms determining altered isoform expression include somatic mutations in splice regulatory sites or altered splicing factors. However, since DNA methylation is known to regulate transcriptional isoform activity in normal cells, we predicted the highly dysregulated patterns of DNA methylation present in cancer also affect isoform activity. We analyzed DNA methylation... Читать дальше...
by Duncan K. Ralph, Frederick A. Matsen IV
The collection of immunoglobulin genes in an individual’s germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In humans, for example, each individual has only a fraction of the several hundred known V alleles. Furthermore, the currently-accepted set of known V alleles is both incomplete (particularly for non-European samples), and contains a significant number of spurious alleles. The... Читать дальше...
by Walter Basile, Marco Salvatore, Claudio Bassot, Arne Elofsson
Intrinsic disorder is more abundant in eukaryotic than prokaryotic proteins. Methods predicting intrinsic disorder are based on the amino acid sequence of a protein. Therefore, there must exist an underlying difference in the sequences between eukaryotic and prokaryotic proteins causing the (predicted) difference in intrinsic disorder. By comparing proteins, from complete eukaryotic and prokaryotic proteomes, we show that the... Читать дальше...
by Xing Chen, Chi-Chi Zhu, Jun Yin
In recent years, increasing associations between microRNAs (miRNAs) and human diseases have been identified. Based on accumulating biological data, many computational models for potential miRNA-disease associations inference have been developed, which saves time and expenditure on experimental studies, making great contributions to researching molecular mechanism of human diseases and developing new drugs for disease treatment. In this paper, we proposed... Читать дальше...
by Christopher J. Bates, Ilker Yildirim, Joshua B. Tenenbaum, Peter Battaglia
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by Erin K. Zess, Cassandra Jensen, Neftaly Cruz-Mireles, Juan Carlos De la Concepcion, Jan Sklenar, Madlen Stephani, Richard Imre, Elisabeth Roitinger, Richard Hughes, Khaoula Belhaj, Karl Mechtler, Frank L. H. Menke, Tolga Bozkurt, Mark J. Banfield, Sophien Kamoun, Abbas Maqbool, Yasin F. Dagdas
Читать дальше...Boris Johnson's plan to consider suspending Parliament in order to force through a no-deal Brexit on October 31, could be ruled illegal. A group of parliamentarians and lawyers are appealing to a Scottish court to seek a guarantee that proroguing Parliament for the purpose of forcing through a no-deal Brexit would be against the law. More »
Thorns return to first place.
Looks like I missed last week’s power rankings due to preparing for a vacation to see the Royals play Portland. As such, here’s the rankings for Wk 14 and 13 (in parenthesis). Once again every team changed positions due to some unexpected results. Looks as if having the international players back actually helps doesn’t it?
So without further mindless banter, here’s the power rankings for week 14. (#) indicates last week’s ranking.
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