Whole-proteome structures shed new light on posttranslational modifications
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by Robbie P. Joosten, Jon Agirre
Accurate but protein-only AlphaFold models may show structural fingerprints of likely posttranslational modifications (PTMs). In this issue of PLOS Biology, Bludau and colleagues add a functional context to models by combining them with readily available proteomics results. In this new age of accurate structure prediction, calculated protein-only models may show the structural fingerprints of likely post-translational modifications. This Primer explores the consequences of a PLOS Biology study which adds a functional context by combining these with readily available proteomics results.