Structural studies offer 'how-to' guide for designing cancer drugs
To design drugs that stall the growth of aggressive cancers, it helps to know the structures of the proteins that are revving the cancers' engines.
To design drugs that stall the growth of aggressive cancers, it helps to know the structures of the proteins that are revving the cancers' engines.
People dealing with the most socioeconomic disadvantages in greater Los Angeles also face higher levels of toxic air pollution, according to a new UCLA-led study.
A surprising discovery from the University of Virginia School of Medicine has torpedoed a key principle used in the development of new drugs to treat diseases. The finding could speed the drug-development process and help prevent potentially harmful drug interactions.
To save the northern white rhinoceros from extinction, the BioRescue team is racing to create lab-grown egg and sperm cells of the critically endangered subspecies. The team has now reported a milestone in Science Advances: they have generated primordial germ cells from stem cells—a world's first.
More than 90% of marine species are undescribed and many may go extinct due to human activity before they're discovered—the loss of unique, potentially valuable genetic resources resulting in unpredictable effects on global ecosystems essential to human food supplies and climate regulation.
Rising temperatures and increasing droughts have scientists looking for ways to better predict how plants will react to stress. Every study offers a little more information. Now, scientists have discovered a way to yield a wealth of insights in a single study. Combining three advanced research techniques that are rarely used together, they found they could pinpoint how different types of plants protect themselves from harsh conditions. Even more surprising? Plants try various strategies to assure their survival.
Non-metal nitrides are compounds in which nitrogen and non-metallic elements are linked by covalent bonds. Because of their technologically interesting properties, they have increasingly become the focus of materials research. In Chemistry—A European Journal, an international team with researchers from the University of Bayreuth presents previously unknown phosphorus-nitrogen compounds synthesized under very high pressures.
An international team of astronomers has used data from NASA's James Webb Space Telescope to report the discovery of the earliest galaxies confirmed to date. The light from these galaxies has taken more than 13.4 billion years to reach us, as these galaxies date back to less than 400 million years after the big bang, when the universe was only 2% of its current age.
A biocompatible polymer could help deliver vaccines and drugs with reduced risk of the rare dangerous adverse reaction called anaphylaxis. Researchers at the National Institute of Advanced Industrial Science and Technology (AIST) in Japan have developed the polymer and performed preliminary tests, which they report in the journal Science and Technology of Advanced Materials.
Two-dimensional materials, like transition metal dichalcogenide, have applications in public health because of their large surface area and high surface sensitivities, along with their unique electrical, optical, and electrochemical properties. A research team has undertaken a review study of methods used to modulate the properties of two-dimensional transition metal dichalcogenide (TMD). These methods have important biomedical applications, including biosensing.
Using new gene mapping methods, researchers have found connections between atopic dermatitis (eczema) in dogs and several regions of the genome. Some of the genes identified coincide with genes linked to similar problems in humans. The filaggrin gene region, for example, which is regarded as the most powerful risk factor for atopic eczema in humans, has now also been linked to this disease in Labrador retrievers.
Since 2017, nearly 3,000 young Norwegians aged 17 to 20 have shared in their own words what they consider important in Norwegian society, and whom they regard as good role models.
Sunday at around 10:40 a.m. MT, NASA's Orion spacecraft will splash down in the Pacific Ocean after its several week-long journey to the moon and back. Space buffs can tune into NASA's livestream to witness some extreme physics—what will be the last leg of the historic Artemis 1 mission, which launched from Florida Nov. 15.
Scientists from the International Livestock Research Institute (ILRI), the University of Liverpool, the University of Edinburgh and elsewhere have traced how livestock systems act as a reservoir for antimicrobial-resistant (AMR) bacteria and AMR genetic determinants that may infect or colonize people.
The quantum receiver is an elementary component in quantum information processing tasks. It aims to extract necessary information from non-orthogonal quantum states. Due to the nature of shot noise, signals carried by electromagnetic waves show non-orthogonal quantum features after suffering a severe loss, such as during interstellar communication. Therefore, the quantum receiver is the only apparatus to decode these weak signals with an error rate below the shot-noise limit.
The Large Hadron Collider Beauty (LHCb) experiment at CERN is the world's leading experiment in quark flavor physics with a broad particle physics program. Its data from Runs 1 and 2 of the Large Hadron Collider (LHC) has so far been used for over 600 scientific publications, including a number of significant discoveries.
Star clusters tend to host more hot Jupiters than average, but why? A team of astronomers have proposed a new solution, and it involves a lot of swapping of stellar neighbors.
A USC study of Instagram shows that a picture and a video are worth more than just a thousand words. They can fuel a human rights movement.
A team of researchers based at the University of Rhode Island and Binghamton University has launched the world's largest quantitative dataset on global human rights.
Glacier mass balance is one of the most important parameters characterizing glacier changes. However, the scarcity of glacier mass balance and meteorological data in the glacier area limits our understanding of glacier changes in the Tianshan Mountains.
Dr. Chelsea Hu, an assistant professor in the Artie McFerrin Department of Chemical Engineering at Texas A&M University and a member of the Accountability, Climate, Equity, and Scholarship (ACES) Faculty Fellows Program, is using synthetic biology to help scientists control genetically engineered cells. Her study is the first to use modeling and a physical experiment to show the effectiveness of layered feedback mechanisms. Hu collaborated with Dr. Richard Murray at the California Institute of Technology.
Clues to a black hole's origins can be found in the way it spins. This is especially true for binaries, in which two black holes circle close together before merging. The spin and tilt of the respective black holes just before they merge can reveal whether the invisible giants arose from a quiet galactic disk or a more dynamic cluster of stars.
As the supply of unsold housing increases in Utah—and across the nation—and as home prices continue to fall, new research coauthored by a BYU Marriott School of Business professor has discovered under-the-radar forces that are quietly impacting home pricing and purchasing decisions.
Atomic clocks are crucial for everyday living as they help our telecommunications, electrical power grids, GPS systems, transportation, and other processes around the world keep precise time. Some of these clocks use lasers and special resonator cavities to measure time intervals. They are some of the most accurate clocks in the world and the most fragile.
Dugongs—large herbivorous marine mammals commonly known as "sea cows"—are now threatened with extinction, according to an official list updated Friday.
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